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50 mg of trazodone for sleep (i.p.), 5 mg of clonazepam for sleep (e.g., a mild dose for nightmares) or 1 mg of diazepam in the morning (i.e., a moderate dose for waking up in the morning) for insomnia (Wiekerb et al., 2008). For a total of 7 days, the patient had an average dose of 2.1 mg trazodone and 1.5 of clonazepam in the morning, followed by 5 mg of diazepam in the evening, with a total of 5 doses trazodone plus clonazepam diazepam. These doses may appear much too high (the lowest 1.5 Cialis 60 Pills 20mg $179 - $2.98 Per pill mg dose in the example would be about 10 times the typical dose of diazepam), but the average diazepam dose of 1 mg in healthy individuals is the 0.4–1 mg range, and 1 is equivalent to 1–2 mg of diazepam or to generic cialis with free shipping 5–10 mg of trazodone (Farnworth et al., 1992; Parekh 2010). However, if it is assumed that the patient's average daily dose had been lower by the time of study, it is possible that the trazodone and clonazepam doses were closer to the therapeutic range and dosages of diazepam were closer to the clinical range. It is noteworthy that the duration of trazodone or clonazepam interventions was typically around 7 days, and the combination of trazodone clonazepam seems to be useful for the most severe problems. It is less clear what to make of the combination clonazepam and trazodone in the case of symptoms a short duration (e.g., in the immediate wakefulness), especially for patients with long histories of alcohol-related problems. A significant amount of literature on the combination clonazepam with trazodone has been published (e.g., Filippi et al., 2001). The combination may have same effects as the two medications in same drug class combined, such as the anxiolytic and sedative effects of diazepam, but the clinical outcomes may be different because of the additional side effects, and particularly because of increased toxicity at higher doses of clonazepam. Clonazepam is rapidly metabolized to the much toxic benzodiazepine zolpidem, which is eliminated by renal tubular excretion. The metabolite of clonazepam (dizocilpine) and zolpidem had even higher clearance rates. When the drug was compared with diazepam (Mozambique et al., 2001), the drug.
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